Methotrexate (MTX) (high dose only)

Test/Investigation

Methotrexate (MTX) (high dose only)

Site(s) or Laboratory offering Test/Investigation

NNUH

Units

µmol/L

Comments/Precautions

URGENT TEST Protect from light. Contact Consultant Haematologist. Seek prior arrangement with Biochemistry on Ext. 6047 Sample needs to be brought to the laboratory immediately.

Sample type

Serum

Turnaround times (TAT) Urgent/Routine/GP or OPD

As required

Reference intervals (adult unless stated)

Following a high dose methotrexate treatment, the levels indicated below are at increased risk of toxicity:
24 hours = >10 µmol/L
48 hours = >1.0 µmol/L
72 hours = 0.1 µmol/L

If UKAS Accredited Test indicate at which site

Y NNUH

Source

http://www.ctc.ucl.ac.uk/TrialDocuments/Uploaded/UKALL14%20-%20Protocol%20-%20v5.0%2020.07.12%20plus%20errata%2004.02.14_12042017_0.pdf