Test/Investigation
Methotrexate (MTX) (high dose only)
Site(s) or Laboratory offering Test/Investigation
NNUH (Biochemistry)
Units
µmol/L
Comments/Precautions
URGENT TEST Protect from light. Contact Consultant Haematologist. Seek prior arrangement with Biochemistry on Ext. 6047 Sample needs to be brought to the laboratory immediately.
Sample type
Serum
Turnaround times (TAT) Urgent/Routine/GP or OPD
As required
Reference intervals (adult unless stated)
Following a high dose methotrexate treatment, the levels indicated below are at increased risk of toxicity:
24 hours = >10 µmol/L
48 hours = >1.0 µmol/L
72 hours = 0.1 µmol/L
If UKAS Accredited Test indicate at which site
Y NNUH
Source
http://www.ctc.ucl.ac.uk/TrialDocuments/Uploaded/UKALL14%20-%20Protocol%20-%20v5.0%2020.07.12%20plus%20errata%2004.02.14_12042017_0.pdf